Fibroblast Activation Protein Expressing Mesenchymal Cells Promote Glioblastoma Angiogenesis.

ABSTRACT: Fibroblast activation protein (FAP) is a membrane-bound protease that is upregulated in a wide range of tumours and viewed as a marker of tumour-promoting stroma. Previously, we demonstrated increased FAP expression in glioblastomas and described its localisation in cancer and stromal cells. In this study, we show that FAP+ stromal cells are mostly localised in the vicinity of activated CD105+ endothelial cells and their quantity positively correlates with glioblastoma vascularisation. FAP+ mesenchymal cells derived from human glioblastomas are non-tumorigenic and mostly lack the cytogenetic aberrations characteristic of glioblastomas. Conditioned media from these cells induce angiogenic sprouting and chemotaxis of endothelial cells and promote migration and growth of glioma cells. In a ch

SUBMITTER: Balaziova E 

PROVIDER: S-EPMC8267680 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature