Liver Disease: Induction, Progression, Immunological Mechanisms, and Therapeutic Interventions.

ABSTRACT: The liver is an organ with impressive regenerative potential and has been shown to heal sizable portions after their removal. However, certain diseases can overstimulate its potential to self-heal and cause excessive cellular matrix and collagen buildup. Decompensation of liver fibrosis leads to cirrhosis, a buildup of fibrotic ECM that impedes the liver's ability to efficiently exchange fluid. This review summarizes the complex immunological activities in different liver diseases, and how failure to maintain liver homeostasis leads to progressive fibrotic tissue development. We also discuss a variety of pathologies that lead to liver cirrhosis, such as alcoholic liver disease and chronic hepatitis B virus (HBV). Mesenchymal stem cells are widely studied for their potential in tissue repla

SUBMITTER: Neshat SY 

PROVIDER: S-EPMC8267746 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature