Epigenetics of Most Aggressive Solid Tumors: Pathways, Targets and Treatments.

ABSTRACT: Highly aggressive tumors are characterized by a highly invasive phenotype, and they display chemoresistance. Furthermore, some of the tumors lack expression of biomarkers for target therapies. This is the case of small-cell lung cancer, triple-negative breast cancer, pancreatic ductal adenocarcinoma, glioblastoma, metastatic melanoma, and advanced ovarian cancer. Unfortunately, these patients show a low survival rate and most of the available drugs are ineffective. In this context, epigenetic modifications have emerged to provide the causes and potential treatments for such types of tumors. Methylation and hydroxymethylation of DNA, and histone modifications, are the most common targets of epigenetic therapy, to influence gene expression without altering the DNA sequence. These modificatio

SUBMITTER: Martinez-Useros J 

PROVIDER: S-EPMC8267921 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature