Early Transcriptional Liver Signatures in Experimental Visceral Leishmaniasis.

ABSTRACT: Transcriptional analysis of complex biological scenarios has been used extensively, even though sometimes the results of such analysis may prove imprecise or difficult to interpret due to an overwhelming amount of information. In this study, a large-scale real-time qPCR experiment was coupled to multivariate statistical analysis in order to describe the main immunological events underlying the early L. infantum infection in livers of BALB/c mice. High-throughput qPCR was used to evaluate the expression of 223 genes related to immunological response and metabolism 1, 3, 5, and 10 days post infection. This integrative analysis showed strikingly different gene signatures at 1 and 10 days post infection, revealing the progression of infection in the experimental model based on the upreg

SUBMITTER: Palacios G 

PROVIDER: S-EPMC8267970 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature