Genetically predicted circulating concentrations of micronutrients and risk of breast cancer: A Mendelian randomization study.

ABSTRACT: The epidemiological literature reports inconsistent associations between consumption or circulating concentrations of micronutrients and breast cancer risk. We investigated associations between genetically predicted concentrations of 11 micronutrients (beta-carotene, calcium, copper, folate, iron, magnesium, phosphorus, selenium, vitamin B₆ , vitamin B₁₂ and zinc) and breast cancer risk using Mendelian randomization (MR). A two-sample MR study was conducted using 122 977 women with breast cancer and 105 974 controls from the Breast Cancer Association Consortium. MR analyses were conducted using the inverse variance-weighted approach, and sensitivity analyses were conducted to assess the impact of potential violations of MR assumptions. A value of 1 SD (SD: 0.08 mmol/L

SUBMITTER: Papadimitriou N 

PROVIDER: S-EPMC8268064 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature