Obesity Causes Abrupt Changes in the Testicular Microbiota and Sperm Motility of Zebrafish.

ABSTRACT:

Background

Obesity is a recognized risk factor for low fertility and is becoming increasingly prevalent in many countries around the world. Obesity changes intestinal microbiota composition, causes inflammation of various organs, and also reduces sperm quality. Several microorganisms are present in the testis. However, whether obesity affects the changes of testicular microbiota and whether these changes are related to reduced fertility in obese men remain to be elucidated.

Methods

In the present study, a zebrafish obesity model was established by feeding with egg yolk powder. Sperm motility was measured by the Computer Assisted Sperm Analysis system, testicular microbial communities was assessed via 16s RNA sequencing, the immune response in zebrafish testis was quan

SUBMITTER: Su Y 

PROVIDER: S-EPMC8268156 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature