Pharmacokinetic evaluation of Chalcone derivatives with antimalarial activity in New Zealand White Rabbits.

ABSTRACT:

Objective

Malaria is a major global health concern with the urgent need for new treatment alternatives due to the alarming increase of drug-resistant Plasmodium strains. Chalcones and its derivatives are important pharmacophores showing antimalarial activity. Determination of the pharmacokinetic variables at the preliminary step of drug development for any drug candidates is an essential component of in vivo antimalarial efficacy tests. Substandard pharmacokinetic variables are often responsible for insufficient therapeutic effect. Therefore, three chalcone derivatives, 1, 2, and 3, having antimalarial potency were studied further for potential therapeutic efficacy.

Results

In vivo pharmacokinetic studies of these three derivatives were performed on New Zealand White rabbits

SUBMITTER: Sinha S 

PROVIDER: S-EPMC8268181 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature