Ontology highlight
ABSTRACT:
SUBMITTER: Tong HY
PROVIDER: S-EPMC8268204 | biostudies-literature | 2021 Jun
REPOSITORIES: biostudies-literature
Tong Hoi Yan HY Borobia Alberto M AM Quintana-Díaz Manuel M Fabra Sara S González-Viñolis Manuel M Fernández-Capitán Carmen C Rodriguez-Dávila María A MA Lorenzo Alicia A López-Parra Ana María AM Ruiz-Giménez Nuria N Abad-Santos Francisco F Suarez Carmen C Madridano Olga O Gómez-Cerezo Jorge Francisco JF Llamas Pilar P Baeza-Richer Carlos C Arroyo-Pardo Eduardo E Carcas Antonio J AJ The Pgx-Ace Spanish Investigators Group
Journal of clinical medicine 20210630 13
Patients with venous thromboembolism (VTE) require immediate treatment with anticoagulants such as acenocoumarol. This multicentre randomised clinical trial evaluated the effectiveness of a dosing pharmacogenetic algorithm versus a standard-of-care dose adjustment at the beginning of acenocoumarol treatment. We included 144 patients with VTE. On the day of recruitment, a blood sample was obtained for genotyping (<i>CYP2C9*2</i>, <i>CYP2C9*3</i>, <i>VKORC1</i>, <i>CYP4F2</i>, <i>APOE</i>). Dose a ...[more]