Construction of lncRNA-related competing endogenous RNA network and identification of hub genes in recurrent implantation failure.

ABSTRACT:

Background

The mechanism of recurrent implantation failure (RIF) is unclear at present and poor endometrial receptivity may be one of the leading reasons. This study aims to construct a competing endogenous RNA (ceRNA) network and identify potential hub genes underlying the development of RIF.

Methods

Weighted gene co-expression network analysis was performed based on differentially expressed mRNAs (DEMs) and lncRNAs (DELs) from the GSE111974 dataset. Functional enrichment analyses of gene modules were conducted using Gene Ontology classification and Kyoto Encyclopedia of Genes and Genomes pathway. A lncRNA-miRNA-mRNA ceRNA regulatory network was constructed according to predictive interaction derived from the LncRNADisease, miRTarBase, miRDB and TargetScan databases. Topolo

SUBMITTER: Huang J 

PROVIDER: S-EPMC8268333 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature