Non-steroidal anti-inflammatory drugs and bone healing in animal models-a systematic review and meta-analysis.

ABSTRACT:

Background

Non-steroidal anti-inflammatory drugs (NSAID) have excellent anti-inflammatory and analgesic properties and are extensively used to treat post-traumatic or surgical musculoskeletal pain. Although an extensive literature exists on the administration of NSAID on animal bone healing, no systematic review and meta-analysis of animal studies that investigate the effect of NSAID administration on bone fracture healing. Objective of this study is to conduct a systematic review and meta-analysis to estimate the effect of NSAIDs administration on bone healing biomechanical and histomorphometric measurements in different animal models after bone fracture surgery.

Methods

We performed a systematic review and meta-analysis of animal studies to estimate the effect of NSAID adm

SUBMITTER: Al-Waeli H 

PROVIDER: S-EPMC8268344 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature