The correlation of next-generation sequencing-based genotypic profiles with clinicopathologic characteristics in NPM1-mutated acute myeloid leukemia.

ABSTRACT: The purpose of this study was to analyze the association between next-generation sequencing (NGS) genotypic profiles and conventional clinicopathologic characteristics in patients with acute myeloid leukemia (AML) with NPM1 mutation (NPM1^mut). We selected 238 NPM1^mut patients with available NGS information on 112 genes related to blood diseases using the χ2 and Mann-Whitney U tests and a multivariable logistic model to analyze the correlation between genomic alterations and clinicopathologic parameters. Compared with the NPM1^mut/FLT3-ITD^(-) group, the NPM1^mut/FLT3-ITD⁽⁺⁾ group presented borderline frequent M5 morphology [78/143 (54.5%) vs. 64/95 (67.4%); P = 0.048], higher CD34- and CD7-positive rates (CD34: 20.6% vs. 47.9%,

SUBMITTER: Wang B 

PROVIDER: S-EPMC8268444 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature