Gene-gene and gene-environment interactions on cord blood total IgE in Chinese Han children.

ABSTRACT:

Background

IL13, IL4, IL4RA, FCER1B and ADRB2 are susceptible genes of asthma and atopy. Our previous study has found gene-gene interactions on asthma between these genes in Chinese Han children. Whether the interactions begin in fetal stage, and whether these genes interact with prenatal environment to enhance cord blood IgE (CBIgE) levels and then cause subsequent allergic diseases have yet to be determined. This study aimed to determine whether there are gene-gene and gene-environment interactions on CBIgE elevation among the aforementioned five genes and prenatal environmental factors in Chinese Han population.

Methods

989 cord blood samples from a Chinese birth cohort were genotyped for nine single-nucleotide polymorphisms (SNPs) in the five genes, and measured for CBIg

SUBMITTER: Hua L 

PROVIDER: S-EPMC8268446 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature