A machine learning approach for accurate and real-time DNA sequence identification.

ABSTRACT:

Background

The all-electronic Single Molecule Break Junction (SMBJ) method is an emerging alternative to traditional polymerase chain reaction (PCR) techniques for genetic sequencing and identification. Existing work indicates that the current spectra recorded from SMBJ experimentations contain unique signatures to identify known sequences from a dataset. However, the spectra are typically extremely noisy due to the stochastic and complex interactions between the substrate, sample, environment, and the measuring system, necessitating hundreds or thousands of experimentations to obtain reliable and accurate results.

Results

This article presents a DNA sequence identification system based on the current spectra of ten short strand sequences, including a pair that differs by a

SUBMITTER: Wang Y 

PROVIDER: S-EPMC8268518 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature