Six Decades of Research on Human Fetal Gonadal Steroids.

ABSTRACT: Human fetal gonads acquire endocrine steroidogenic capabilities early during their differentiation. Genetic studies show that this endocrine function plays a central role in the sexually dimorphic development of the external genitalia during fetal development. When this endocrine function is dysregulated, congenital malformations and pathologies are the result. In this review, we explain how the current knowledge of steroidogenesis in human fetal gonads has benefited from both the technological advances in steroid measurements and the assembly of detailed knowledge of steroidogenesis machinery and its expression in human fetal gonads. We summarise how the conversion of radiolabelled steroid precursors, antibody-based assays, mass spectrometry, ultrastructural studies, and the in situ label

SUBMITTER: Connan-Perrot S 

PROVIDER: S-EPMC8268622 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature