Expression Pattern of Leptin and Its Receptors in Endometrioid Endometrial Cancer.

ABSTRACT: The identification of novel molecular markers and the development of cancer treatment strategies are very important as cancer incidence is still very high. Obesity can contribute to cancer progression, including endometrial cancer. Adipocytes secrete leptin, which, when at a high level, is associated with an increased risk of cancer. The aim of this study was to determine the expression profile of leptin-related genes in the endometrial tissue samples and whole blood of patients. The study material included tissue samples and whole blood collected from 30 patients with endometrial cancer and 30 without cancer. Microarrays were used to assess the expression profile of leptin-related genes. Then, the expression of leptin (LEP), leptin receptor (LEPR), leptin receptor overlapping transcript (

SUBMITTER: Boron D 

PROVIDER: S-EPMC8268664 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature