D-dimer, thrombin generation, and risk of a first venous thrombosis in the elderly.

ABSTRACT:

Background

A high D-dimer level and parameters of the thrombin generation (TG) potential are associated with the risk of a first venous thrombosis (VT) in young and middle-aged populations.

Objectives

To investigate whether D-dimer and TG potential (lag-time, time-to-peak [ttPeak], peak thrombin, endogenous thrombin potential [ETP], and velocity index), are associated with the risk of a first VT in those aged 70 years and older.

Methods

We included 215 patients with a first VT and 358 controls, all aged >70 years, from the Age and Thrombosis, Acquired and Genetic Risk Factors in the Elderly (AT-AGE) study. To assess the risk of VT, odds ratios with 95% confidence intervals (CIs) were estimated using logistic regression analysis.

Results

D-dimer and all TG param

SUBMITTER: Wang H 

PROVIDER: S-EPMC8268666 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature