New Angiogenic Regulators Produced by TAMs: Perspective for Targeting Tumor Angiogenesis.

ABSTRACT: Angiogenesis is crucial to the supply of a growing tumor with nutrition and oxygen. Inhibition of angiogenesis is one of the main treatment strategies for colorectal, lung, breast, renal, and other solid cancers. However, currently applied drugs that target VEGF or receptor tyrosine kinases have limited efficiency, which raises a question concerning the mechanism of patient resistance to the already developed drugs. Tumor-associated macrophages (TAMs) were identified in the animal tumor models as a key inducer of the angiogenic switch. TAMs represent a potent source not only for VEGF, but also for a number of other pro-angiogenic factors. Our review provides information about the activity of secreted regulators of angiogenesis produced by TAMs. They include members of SEMA and S100A famili

SUBMITTER: Larionova I 

PROVIDER: S-EPMC8268686 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature