The Role of ABCG2 in the Pathogenesis of Primary Hyperuricemia and Gout-An Update.

ABSTRACT: Urate homeostasis in humans is a complex and highly heritable process that involves i.e., metabolic urate biosynthesis, renal urate reabsorption, as well as renal and extrarenal urate excretion. Importantly, disturbances in urate excretion are a common cause of hyperuricemia and gout. The majority of urate is eliminated by glomerular filtration in the kidney followed by an, as yet, not fully elucidated interplay of multiple transporters involved in the reabsorption or excretion of urate in the succeeding segments of the nephron. In this context, genome-wide association studies and subsequent functional analyses have identified the ATP-binding cassette (ABC) transporter ABCG2 as an important urate transporter and have highlighted the role of single nucleotide polymorphisms (SNPs) in the pat

SUBMITTER: Eckenstaler R 

PROVIDER: S-EPMC8268734 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature