PGC1s and Beyond: Disentangling the Complex Regulation of Mitochondrial and Cellular Metabolism.

ABSTRACT: Metabolism is the central engine of living organisms as it provides energy and building blocks for many essential components of each cell, which are required for specific functions in different tissues. Mitochondria are the main site for energy production in living organisms and they also provide intermediate metabolites required for the synthesis of other biologically relevant molecules. Such cellular processes are finely tuned at different levels, including allosteric regulation, posttranslational modifications, and transcription of genes encoding key proteins in metabolic pathways. Peroxisome proliferator activated receptor γ coactivator 1 (PGC1) proteins are transcriptional coactivators involved in the regulation of many cellular processes, mostly ascribable to metabolic pathways. Here

SUBMITTER: Coppi L 

PROVIDER: S-EPMC8268830 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature