NEUROD1 Is Required for the Early α and β Endocrine Differentiation in the Pancreas.

ABSTRACT: Diabetes is a metabolic disease that involves the death or dysfunction of the insulin-secreting β cells in the pancreas. Consequently, most diabetes research is aimed at understanding the molecular and cellular bases of pancreatic development, islet formation, β-cell survival, and insulin secretion. Complex interactions of signaling pathways and transcription factor networks regulate the specification, growth, and differentiation of cell types in the developing pancreas. Many of the same regulators continue to modulate gene expression and cell fate of the adult pancreas. The transcription factor NEUROD1 is essential for the maturation of β cells and the expansion of the pancreatic islet cell mass. Mutations of the Neurod1 gene cause diabetes in humans and mice. However, the different aspec

SUBMITTER: Bohuslavova R 

PROVIDER: S-EPMC8268837 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature