Exploring a combined biomarker for tuberculosis treatment response: protocol for a prospective observational cohort study.

ABSTRACT:

Introduction

An improved understanding of factors explaining tuberculosis (TB) treatment response is urgently needed to help clinicians optimise and personalise treatment and assist scientists undertaking novel treatment regimen trials. Promising outcome proxy measures, including sputum bacillary load and host immune response, are widely reported with variable results. However, they have not been studied together in combination with antibiotic exposure. The aim of this observational cohort study is to investigate which antibiotic exposures correlate with sputum bacillary load and which with the host immune response. Subsequently, we will explore if these correlations can be used to inform a candidate combined biomarker predicting cure.

Methods and analysis

All patients aged

SUBMITTER: Kloprogge F 

PROVIDER: S-EPMC8268918 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature