Prognostic Factors for Wilms Tumor Recurrence: A Review of the Literature.

ABSTRACT: In high-income countries, the overall survival of children with Wilms tumors (WT) is ~90%. However, overall, 15% of patients experience tumor recurrence. The adverse prognostic factors currently used for risk stratification (advanced stage, high risk histology, and combined loss of heterozygosity at 1p and 16q in chemotherapy-naïve WTs) are present in only one third of these cases, and the significance of these factors is prone to change with advancing knowledge and improved treatment regimens. Therefore, we present a comprehensive, updated overview of the published prognostic variables for WT recurrence, ranging from patient-, tumor- and treatment-related characteristics to geographic and socioeconomic factors. Improved first-line treatment regimens based on clinicopathological characteri

SUBMITTER: Groenendijk A 

PROVIDER: S-EPMC8268923 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature