The LPA₃ Receptor: Regulation and Activation of Signaling Pathways.

ABSTRACT: The lysophosphatidic acid 3 receptor (LPA₃) participates in different physiological actions and in the pathogenesis of many diseases through the activation of different signal pathways. Knowledge of the regulation of the function of the LPA₃ receptor is a crucial element for defining its roles in health and disease. This review describes what is known about the signaling pathways activated in terms of its various actions. Next, we review knowledge on the structure of the LPA₃ receptor, the domains found, and the roles that the latter might play in ligand recognition, signaling, and cellular localization. Currently, there is some information on the action of LPA₃ in different cells and whole organisms, but very little is known about the regulation

SUBMITTER: Solis KH 

PROVIDER: S-EPMC8269014 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature