Metabolites of the ring-substituted stimulants MDMA, methylone and MDPV differentially affect human monoaminergic systems.

ABSTRACT:

Background

Amphetamine analogs with a 3,4-methylenedioxy ring-substitution are among the most popular illicit drugs of abuse, exerting stimulant and entactogenic effects. Enzymatic N-demethylation or opening of the 3,4-methylenedioxy ring via O-demethylenation gives rise to metabolites that may be pharmacologically active. Indeed, previous studies in rats show that specific metabolites of 3,4-methylenedioxymethamphetamine (MDMA), 3,4-methylenedioxymethcathinone (methylone) and 3,4-methylenedioxypyrovalerone (MDPV) can interact with monoaminergic systems.

Aim

Interactions of metabolites of MDMA, methylone and MDPV with human monoaminergic systems were assessed.

Methods

The ability of parent drugs and their metabolites to inhibit uptake of tritiated norepi

SUBMITTER: Luethi D 

PROVIDER: S-EPMC8269116 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature