Component Parts of Bacteriophage Virions Accurately Defined by a Machine-Learning Approach Built on Evolutionary Features.

ABSTRACT: Antimicrobial resistance (AMR) continues to evolve as a major threat to human health, and new strategies are required for the treatment of AMR infections. Bacteriophages (phages) that kill bacterial pathogens are being identified for use in phage therapies, with the intention to apply these bactericidal viruses directly into the infection sites in bespoke phage cocktails. Despite the great unsampled phage diversity for this purpose, an issue hampering the roll out of phage therapy is the poor quality annotation of many of the phage genomes, particularly for those from infrequently sampled environmental sources. We developed a computational tool called STEP³ to use the "evolutionary features" that can be recognized in genome sequences of diverse phages. These features, when integ

SUBMITTER: Thung TY 

PROVIDER: S-EPMC8269216 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature