Early-Life Immune System Maturation in Chickens Using a Synthetic Community of Cultured Gut Bacteria.

ABSTRACT: The gut microbiome is crucial for both maturation of the immune system and colonization resistance against enteric pathogens. Although chicken are important domesticated animals, the impact of their gut microbiome on the immune system is understudied. Therefore, we investigated the effect of microbiome-based interventions on host mucosal immune responses. Increased levels of IgA and IgY were observed in chickens exposed to maternal feces after hatching compared with strict hygienic conditions. This was accompanied by increased gut bacterial diversity as assessed by 16S rRNA gene amplicon sequencing. Cultivation work allowed the establishment of a collection of 43 bacterial species spanning 4 phyla and 19 families, including the first cultured members of 3 novel genera and 4 novel species t

SUBMITTER: Zenner C 

PROVIDER: S-EPMC8269260 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature