Predicted Metabolic Function of the Gut Microbiota of Drosophila melanogaster.

ABSTRACT: An important goal for many nutrition-based microbiome studies is to identify the metabolic function of microbes in complex microbial communities and their impact on host physiology. This research can be confounded by poorly understood effects of community composition and host diet on the metabolic traits of individual taxa. Here, we investigated these multiway interactions by constructing and analyzing metabolic models comprising every combination of five bacterial members of the Drosophila gut microbiome (from single taxa to the five-member community of Acetobacter and Lactobacillus species) under three nutrient regimes. We show that the metabolic function of Drosophila gut bacteria is dynamic, influenced by community composition, and responsive to dietary modu

SUBMITTER: Ankrah NYD 

PROVIDER: S-EPMC8269265 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature