OB-Folds and Genome Maintenance: Targeting Protein-DNA Interactions for Cancer Therapy.

ABSTRACT: Genome stability and maintenance pathways along with their requisite proteins are critical for the accurate duplication of genetic material, mutation avoidance, and suppression of human diseases including cancer. Many of these proteins participate in these pathways by binding directly to DNA, and a subset employ oligonucleotide/oligosaccharide binding folds (OB-fold) to facilitate the protein-DNA interactions. OB-fold motifs allow for sequence independent binding to single-stranded DNA (ssDNA) and can serve to position specific proteins at specific DNA structures and then, via protein-protein interaction motifs, assemble the machinery to catalyze the replication, repair, or recombination of DNA. This review provides an overview of the OB-fold structural organization of some of the most rel

SUBMITTER: Par S 

PROVIDER: S-EPMC8269290 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature