Product Distributions of Cytochrome P450 OleT_JE with Phenyl-Substituted Fatty Acids: A Computational Study.

ABSTRACT: There are two types of cytochrome P450 enzymes in nature, namely, the monooxygenases and the peroxygenases. Both enzyme classes participate in substrate biodegradation or biosynthesis reactions in nature, but the P450 monooxygenases use dioxygen, while the peroxygenases take H₂O₂ in their catalytic cycle instead. By contrast to the P450 monooxygenases, the P450 peroxygenases do not require an external redox partner to deliver electrons during the catalytic cycle, and also no external proton source is needed. Therefore, they are fully self-sufficient, which affords them opportunities in biotechnological applications. One specific P450 peroxygenase, namely, P450 OleT_JE, reacts with long-chain linear fatty acids through oxidative decarboxylation to form hydroc

SUBMITTER: Lin YT 

PROVIDER: S-EPMC8269385 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature