Emerging Prospects for Combating Fungal Infections by Targeting Phosphatidylinositol Transfer Proteins.

ABSTRACT: The emergence of fungal "superbugs" resistant to the limited cohort of anti-fungal agents available to clinicians is eroding our ability to effectively treat infections by these virulent pathogens. As the threat of fungal infection is escalating worldwide, this dwindling response capacity is fueling concerns of impending global health emergencies. These developments underscore the urgent need for new classes of anti-fungal drugs and, therefore, the identification of new targets. Phosphoinositide signaling does not immediately appear to offer attractive targets due to its evolutionary conservation across the Eukaryota. However, recent evidence argues otherwise. Herein, we discuss the evidence identifying Sec14-like phosphatidylinositol transfer proteins (PITPs) as unexplored portals through

SUBMITTER: Khan D 

PROVIDER: S-EPMC8269425 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature