Bioactive metabolites of Blumea lacera attenuate anxiety and depression in rodents and computer-aided model.

ABSTRACT: Blumea lacera is an edible plant with imperative medicinal values. However, the anxiolytic and antidepressant roles of B. lacera have not been well-explained. Therefore, the current study aims to explore the impending bioactive metabolites and roles of B. lacera methanol leaf extract (Me-BLL) in attenuating anxiety and depression through several experimental and computer-aided approaches. The chemical characterization of Me-BLL was performed through standard phytochemical and GC-MS analyses. To explore the neuropharmacological insights, Swiss albino mice were treated with Me-BLL at doses of 200-400 mg/kg, p.o. The anxiolytic effects were observed employing elevated plus maze (EPM), light-dark box (LDB), and hole-board (HBT) tests, while antidepressant effects were eval

SUBMITTER: Hossen MA 

PROVIDER: S-EPMC8269660 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature