Ameliorative impacts of Glycyrrhiza glabra root extract against nephrotoxicity induced by gentamicin in mice.

ABSTRACT: Gentamicin is an effective antibiotic that has been used worldwide for many years. While considered an essential medicine by the WHO, gentamicin can also lead to severe kidney damage. This study explored the ameliorative effects of Glycyrrhiza glabra root extract on gentamicin-induced renal injury in mice. Four groups of n = 7 mice were used: (a) control; (b) G. glabra-only; (c) gentamicin-only; and (d) gentamicin plus G. glabra. Kidney samples were tested for: antioxidant enzyme activity (superoxide dismutase [SOD] and glutathione peroxidase [Gpx]); expression of HO-1 and nuclear factor erythroid 2-related factor 2 genes; expression of Cox-2 and Bax; cytokine levels (IL-1β, and IL-6); histopathological anomalies; and standard renal functional component levels (

SUBMITTER: Nassan MA 

PROVIDER: S-EPMC8269671 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature