Quadrivalent influenza nanoparticle vaccines induce broad protection.

ABSTRACT: Influenza vaccines that confer broad and durable protection against diverse viral strains would have a major effect on global health, as they would lessen the need for annual vaccine reformulation and immunization¹. Here we show that computationally designed, two-component nanoparticle immunogens² induce potently neutralizing and broadly protective antibody responses against a wide variety of influenza viruses. The nanoparticle immunogens contain 20 haemagglutinin glycoprotein trimers in an ordered array, and their assembly in vitro enables the precisely controlled co-display of multiple distinct haemagglutinin proteins in defined ratios. Nanoparticle immunogens that co-display the four haemagglutinins of licensed quadrivalent influenza vaccines elicited antibody resp

SUBMITTER: Boyoglu-Barnum S 

PROVIDER: S-EPMC8269962 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature