Long-term Outcomes from Proton Therapy for Sinonasal Cancers.

ABSTRACT:

Purpose

To report long-term disease control, survival, and toxicity after proton therapy for sinonasal cancer.

Patients and methods

We reviewed 143 cases of adults with nonmetastatic sinonasal cancers treated with primary (18%; n = 26) or adjuvant (82%; n = 117) proton therapy. The most common histologies were squamous cell carcinoma (29%; n = 42), olfactory neuroblastoma (23%; n = 33), and adenoid cystic carcinoma (16%; n = 23). Patients had predominantly advanced-stage disease (T3, 24%, n = 35; T4, 66%, n = 94) and high-grade histology (52%; n = 74). Surgery included endoscopic resection alone (50%) with craniotomy (10%) or open resection (40%), and 31% had gross disease present at radiotherapy. Most (91%) received high-dose (median, 73.6 Gy radiobiological equivalent [GyR

SUBMITTER: Dagan R 

PROVIDER: S-EPMC8270098 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature