Serum adipokine profiles in patients with microscopic polyangiitis and granulomatosis with polyangiitis: An exploratory analysis.

ABSTRACT:

Objectives

Previous studies have shown that adipokines may serve as potential biomarkers reflecting disease activity in various autoimmune diseases. Here, we investigated the relationship between four adipokines and clinical/laboratory findings in patients with microscopic polyangiitis (MPA) and granulomatosis with polyangiitis (GPA).

Methods

Sera from 63 patients with MPA and GPA who were registered in a prospective cohort were used to detect serum levels of adiponectin, chemerin, resistin, and vaspin using commercial enzyme-linked immunosorbent assay kits. Associations between adipokines and clinical and laboratory data was assessed using Pearson's correlation analysis.

Results

The median age was 65.0 years, 24 patients were male, and 42 patients were diagnosed with

SUBMITTER: Ahn SS 

PROVIDER: S-EPMC8270208 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature