An integrative network-based approach for drug target indication expansion.

ABSTRACT:

Background

The identification of a target-indication pair is regarded as the first step in a traditional drug discovery and development process. Significant investment and attrition occur during discovery and development before a molecule is shown to be safe and efficacious for the selected indication and becomes an approved drug. Many drug targets are functionally pleiotropic and might be good targets for multiple indications. Methodologies that leverage years of scientific contributions on drug targets to allow systematic evaluation of other indication opportunities are critical for both patients and drug discovery and development scientists.

Methods

We introduced a network-based approach to systematically screen and prioritize disease indications for drug targets. The app

SUBMITTER: Han Y 

PROVIDER: S-EPMC8270215 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature