Identification of the Impurities in Bopu Powder® and Sangrovit® by LC-MS Combined with a Screening Method.

ABSTRACT: Bopu powder® and Sangrovit® were developed from Macleayacordata and are widely used in agriculture and animal husbandry, but their impurities have been rarely reported in the literature. Impurity analysis is of great importance to the quality and safety of veterinary drugs. In this study, high-performance liquid chromatography/quadrupole time-of-flight mass spectrometry (HPLC-Q-TOF-MS) combined with a screening method was used to screen and characterize the impurities in Bopu powder® and Sangrovit®. A total of 58 impurities were screened from Bopu powder® and Sangrovit® using the screening strategies, of which 39 were identified by their accurate m/z value, characteristic MS/MS data, and fragmentation pathways of references. This established method was used for impurity analysis for the fi

SUBMITTER: Dong Z 

PROVIDER: S-EPMC8270340 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature