Ontology highlight
ABSTRACT:
SUBMITTER: Lin K
PROVIDER: S-EPMC8270425 | biostudies-literature | 2021 Jun
REPOSITORIES: biostudies-literature
Lin Karin K Bieri Gregor G Gontier Geraldine G Müller Sören S Smith Lucas K LK Snethlage Cedric E CE White Charles W CW Maybury-Lewis Sun Y SY Villeda Saul A SA
PLoS biology 20210628 6
Proteins of the major histocompatibility complex class I (MHC I), predominantly known for antigen presentation in the immune system, have recently been shown to be necessary for developmental neural refinement and adult synaptic plasticity. However, their roles in nonneuronal cell populations in the brain remain largely unexplored. Here, we identify classical MHC I molecule H2-Kb as a negative regulator of proliferation in neural stem and progenitor cells (NSPCs). Using genetic knockout mouse mo ...[more]