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The effect of estrogen in coronavirus disease 2019.

ABSTRACT: The outcomes of coronavirus disease 2019 (COVID-19) vary between men and women. Some statistical reports have shown that men have a higher risk of developing COVID-19 and suffer from worse outcomes than females. Although there are many factors that can explain the high prevalence of COVID-19 in men, such as lifestyle habits and the different profile of comorbidities among sexes, the distinctions between male and female immune systems cannot be ignored. It has been sufficiently shown that sex differences have a critical influence on the shaping of immune response, which then leads to different pathogenesis in infectious diseases. Compared with males, females typically have a more effective innate and adaptive immune response to viral infections in COVID-19. What's more, there is a growing body of evidence showing that estrogen exerts an effect on the regulation of immune response. This article examines the effect and mechanism of estrogen on COVID-19.

SUBMITTER: Ma Q

PROVIDER: S-EPMC8270516 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature

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The effect of estrogen in coronavirus disease 2019.

Ma Qing Q Hao Zhuo-Wen ZW Wang Yan-Feng YF

American journal of physiology. Lung cellular and molecular physiology 20210505 1

The outcomes of coronavirus disease 2019 (COVID-19) vary between men and women. Some statistical reports have shown that men have a higher risk of developing COVID-19 and suffer from worse outcomes than females. Although there are many factors that can explain the high prevalence of COVID-19 in men, such as lifestyle habits and the different profile of comorbidities among sexes, the distinctions between male and female immune systems cannot be ignored. It has been sufficiently shown that sex dif ...[more]

PMID: 33949212

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