Identification of potential core genes in esophageal carcinoma using bioinformatics analysis.

ABSTRACT:

Background

Esophageal squamous cell carcinoma (ESCC) is a common human malignancy worldwide. The tumorigenesis mechanism in ESCC is unclear.

Materials and methods

To explore potential therapeutic targets for ESCC, we analyzed 3 microarray datasets (GSE20347, GSE38129, and GSE67269) derived from the gene expression omnibus (GEO) database. Then, the GEO2R tool was used to screen out differently expressed genes (DEGs) between ESCC and normal tissue. Gene ontology function and kyoto encyclopedia of genes and genomes pathway enrichment analysis were performed using the database for annotation, visualization and integrated discovery to identify the pathways and functional annotation of DEGs. Protein-protein interaction of these DEGs was analyzed based on the search tool for the re

SUBMITTER: Yang X 

PROVIDER: S-EPMC8270608 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature