Molecular mechanism of reproductive toxicity induced by Tripterygium Wilfordii based on network pharmacology.

ABSTRACT:

Abstract

To explore the possible molecular mechanism of reproductive toxicity of Tripterygium wilfordii from the perspective of network pharmacology and bioinformatics.The compounds of T wilfordii were obtained by querying the relevant Chinese medicine database, the effective compounds were screened and the corresponding targets were obtained, and then compared with the reproductive toxicities related to disease targets obtained from the disease gene database to infer the potential toxic targets of reproductive toxicity of T wilfordii. Then, the key targets of reproductive toxicity of T wilfordii were screened using Search Tool for the Retrieval of Interacting Genes/Protein and Cytoscape. The gene ontology function and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichme

SUBMITTER: Ding Q 

PROVIDER: S-EPMC8270632 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature