New Computational Approach for Peptide Vaccine Design Against SARS-COV-2.

ABSTRACT: The design for vaccines using in silico analysis of genomic data of different viruses has taken many different paths, but lack of any precise computational approach has constrained them to alignment methods and some alignment-free techniques. In this work, a precise computational approach has been established wherein two new mathematical parameters have been suggested to identify the highly conserved and surface-exposed regions which are spread over a large region of the surface protein of the virus so that one can determine possible peptide vaccine candidates from those regions. The first parameter, w, is the sum of the normalized values of the measure of surface accessibility and the normalized measure of conservativeness, and the second parameter is the area of a triangle formed

SUBMITTER: Biswas S 

PROVIDER: S-EPMC8270779 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature