Human blood microRNA hsa-miR-21-5p induces vitellogenin in the mosquito Aedes aegypti.

ABSTRACT: Mosquito vectors transmit various diseases through blood feeding, required for their egg development. Hence, blood feeding is a major physiological event in their life cycle, during which hundreds of genes are tightly regulated. Blood is a rich source of proteins for mosquitoes, but also contains many other molecules including microRNAs (miRNAs). Here, we found that human blood miRNAs are transported abundantly into the fat body tissue of Aedes aegypti, a key metabolic center in post-blood feeding reproductive events, where they target and regulate mosquito genes. Using an artificial diet spiked with the mimic of an abundant and stable human blood miRNA, hsa-miR-21-5p, and proteomics analysis, we found over 40 proteins showing differential expression in female Ae. aegypti mosquitoes after

SUBMITTER: Perdomo HD 

PROVIDER: S-EPMC8270986 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature