A generative network model of neurodevelopmental diversity in structural brain organization.

ABSTRACT: The formation of large-scale brain networks, and their continual refinement, represent crucial developmental processes that can drive individual differences in cognition and which are associated with multiple neurodevelopmental conditions. But how does this organization arise, and what mechanisms drive diversity in organization? We use generative network modeling to provide a computational framework for understanding neurodevelopmental diversity. Within this framework macroscopic brain organization, complete with spatial embedding of its organization, is an emergent property of a generative wiring equation that optimizes its connectivity by renegotiating its biological costs and topological values continuously over time. The rules that govern these iterative wiring properties are controlle

SUBMITTER: Akarca D 

PROVIDER: S-EPMC8270998 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature