Genetic influences on hub connectivity of the human connectome.
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ABSTRACT:
SUBMITTER: Arnatkeviciute A
PROVIDER: S-EPMC8271018 | biostudies-literature | 2021 Jul
REPOSITORIES: biostudies-literature
Publications
Genetic influences on hub connectivity of the human connectome.
Arnatkeviciute Aurina A Fulcher Ben D BD Oldham Stuart S Tiego Jeggan J Paquola Casey C Gerring Zachary Z Aquino Kevin K Hawi Ziarih Z Johnson Beth B Ball Gareth G Klein Marieke M Deco Gustavo G Franke Barbara B Bellgrove Mark A MA Fornito Alex A
Nature communications 20210709 1
Brain network hubs are both highly connected and highly inter-connected, forming a critical communication backbone for coherent neural dynamics. The mechanisms driving this organization are poorly understood. Using diffusion-weighted magnetic resonance imaging in twins, we identify a major role for genes, showing that they preferentially influence connectivity strength between network hubs of the human connectome. Using transcriptomic atlas data, we show that connected hubs demonstrate tight cou ...[more]
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