Unconjugated bilirubin is associated with protection from early-life wheeze and childhood asthma.

ABSTRACT:

Background

Wheeze and allergic sensitization are the strongest early-life predictors of childhood asthma development; the molecular origins of these early-life phenotypes are poorly understood.

Objectives

We sought to identify metabolites associated with early-life wheeze, allergic sensitization, and childhood asthma.

Methods

We conducted a nested case-control study using Environmental influences on Child Health Outcomes Program cohorts for discovery and independent replication. Wheeze and allergic sensitization were defined by number of wheeze episodes and positive specific IgE at age 1 year, respectively. Asthma was defined as physician diagnosis of asthma at age 5 or 6 years. We used untargeted metabolomics, controlling for observed and latent confounding factors,

SUBMITTER: Turi KN 

PROVIDER: S-EPMC8271087 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature