Co-evolutionary landscape at the interface and non-interface regions of protein-protein interaction complexes.

ABSTRACT: Proteins involved in interactions throughout the course of evolution tend to co-evolve and compensatory changes may occur in interacting proteins to maintain or refine such interactions. However, certain residue pair alterations may prove to be detrimental for functional interactions. Hence, determining co-evolutionary pairings that could be structurally or functionally relevant for maintaining the conservation of an inter-protein interaction is important. Inter-protein co-evolution analysis in several complexes utilizing multiple existing methodologies suggested that co-evolutionary pairings can occur in spatially proximal and distant regions in inter-protein interactions. Subsequently, the Co-Var (Correlated Variation) method based on mutual information and Bhattacharyya co

SUBMITTER: Mukherjee I 

PROVIDER: S-EPMC8271121 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature