Mendelian randomization highlights insomnia as a risk factor for pain diagnoses.

ABSTRACT:

Study objective

Insomnia has been linked to acute and chronic pain conditions; however, it is unclear whether such relationships are causal. Recently, a large number of genetic variants have been discovered for both insomnia and pain through genome-wide association studies (GWASs) providing a unique opportunity to examine the evidence for causal relationships through the use of the Mendelian randomization paradigm.

Methods

To elucidate the causality between insomnia and pain, we performed bidirectional Mendelian randomization analysis in FinnGen, where clinically diagnosed ICD-10 categories of pain had been evaluated. In addition, we used measures of self-reported insomnia symptoms. We used endpoints for pain in the FinnGen Release 5 (R5) (N = 218,379), and a non-overlapping

SUBMITTER: Broberg M 

PROVIDER: S-EPMC8271146 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature