Ontology highlight
ABSTRACT:
SUBMITTER: Schoch KM
PROVIDER: S-EPMC8271763 | biostudies-literature | 2021 Jul
REPOSITORIES: biostudies-literature
Schoch Kathleen M KM Ezerskiy Lubov A LA Morhaus Michaela M MM Bannon Riley N RN Sauerbeck Andrew D AD Shabsovich Mark M Jafar-Nejad Paymaan P Rigo Frank F Miller Timothy M TM
Proceedings of the National Academy of Sciences of the United States of America 20210701 27
Heterozygous genetic variants within the <i>TREM2</i> gene show a strong association with increased Alzheimer's disease (AD) risk. Amyloid beta-depositing mouse models haploinsufficient or null for <i>Trem2</i> have identified important relationships among TREM2, microglia, and AD pathology; however, results are challenging to interpret in the context of varying microglial phenotypes and disease progression. We hypothesized that acute <i>Trem2</i> reduction may alter amyloid pathology and microg ...[more]