WT1 and ACE mRNAs of blood extracellular vesicle as biomarkers of diabetic nephropathy.

ABSTRACT:

Background

Diabetic nephropathy (DN) has an increasing global prevalence with excessive health expenditure and burden. Exosomal mRNAs regulate intercellular communications and participate in the pathogenesis of various disorders like DN. This study aimed to assess the expression levels of ACE, ELMO1, and WT1 mRNAs in the blood extracellular vesicles (EVs) of DN patients and diabetic patients without nephropathy (DM group) in comparison to healthy controls and investigate their correlations with the severity of DN.

Methods

The performed investigation is a cross-sectional study of 256 participants including 103 DN patients, 100 DM patients, and 53 healthy controls. The quantification of WT1, ACE, and ELMO1 mRNAs in the blood EVs were executed using qRT-PCR. The ROC analysis wa

SUBMITTER: Hashemi E 

PROVIDER: S-EPMC8272332 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature